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Gamma Oryzanol is used primarily in the treatment of menopause, elevated cholesterol levels, and various gastrointestinal complaints.
Menopause
Gamma Oryzanol was first shown to be effective in menopausal symptoms, including hot flashes, in the early 1960s. Subsequent studies have further documented its effectiveness in menopause. Its primary action is to reduce the secretion of leutinizing hormone (LH) by the pituitary and promote endorphin release by the hypothalamus.
Elevated Cholesterol Levels
Several studies indicate gamma-oryzanol is quite effective in lowering blood cholesterol and triglyceride levels. Gamma Oryzanol's cholesterol-lowering action appears to involve a combination of effects. It increases the conversion of cholesterol to bile acids, increases bile acid excretion, and inhibits the absorption of cholesterol.
Gastrointestinal complaints
Clinical studies conducted in Japan demonstrate Gamma Oryzanol is effective in the treatment of a broad range of gastrointestinal disorders, including peptic ulcers, gastritis, the irritable bowel syndrome, and nonspecific gastrointestinal complaints. Over 23 clinical studies have been conducted with Gamma Oryzanol in the treatment of these conditions. Its mechanism of action is apparently normalization of nervous system control of digestive secretions | 
